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The EOT of primary CEF by mutants of p110α. The EOT (foci per nanogram of DNA) sets the hot spot mutations apart from the rare mutations and suggests the existence of three categories of rare mutations. Shown are transformation induced by a hot spot mutant (H1047R) and the three rare mutants representative of different oncogenic activity: strong (N345K), intermediate (T1025S), and weak (R38H). The H701P mutant has no detectable phenotype, and the wild-type p110α is also nontransforming.
