Table 1.
Summary of effects resulting from expression of UAS-regulated transgenes
| UAS-transgene
|
Increased cell size
|
Truncated G1
|
Increased clone area
|
Active MAPK
|
Increased dMyc
|
Active dPI3K
|
Round clones
|
Ectopic elav
|
|---|---|---|---|---|---|---|---|---|
| RasV12 | + | + | + | + | + | + | + | + |
| RasV12S35 (MAPK-specific) | + | + | + | + | + | ± | + | + |
| RafGOF (MAPK-specific) | + | + | + | + | + | − | + | + |
| RasV12G37 (dPI3K-specific) | + | + | + | − | − | + | ± | − |
| dPI3K | + | + | + | − | − | + | ± | − |
| dInr | +a | +a | +a | − | − | + | ±a | − |
| dMyc | + | + | + | − | + | − | ± | − |
| dEGFRλtop | +b | +b | N.D. | + | + | − | + | +c |
| RasV12C40 | − | − | − | − | − | − | − | − |
a
A. de la Cruz and B.A. Edgar, unpubl.
b
K. Plow and B.A. Edgar, unpubl.
N.D., Not done.