Figure 3.
Levels of lipid peroxides in STZ-induced diabetic and control rat retinas as determined by the amount of thiobarbituric acid reactivity with malondialdehyde formed during acid hydrolysis of the lipid peroxide. Diabetic retinas had significant increases in formation of lipid peroxides. Treatment of diabetic rats with L-NAME (50 mg/kg/day) or with uric acid (160 mg/kg/day) blocked the increased lipid peroxidation. Data shown is the mean ± SEM of six animals in the treated groups and nine animals in untreated groups. C, control; D, diabetic; *, P < 0.01 versus untreated control; #, P < 0.05 versus untreated diabetic.