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Effect of pH on DIDS-dependent inhibition of intracellular hemoglobin oxidation
| pH | Methemoglobin, %
|
% inhibition by DIDS | |
|---|---|---|---|
| Without DIDS | With DIDS | ||
| 5.5 | 55 ± 2 | 57 ± 3 | 0 |
| 7.0 | 48 ± 2 | 24 ± 2 | 50 |
| 8.2 | 37 ± 2 | 13 ± 1 | 65 |
Peroxynitrite concentrations used were 50 μM at pH 5.5, 150 μM at pH 7.0, and 650 μM at pH 8.2 to achieve similar oxidation yields.
