Table 2.
(a) Top association results for mean BMI and mean WC based on GEE p-value; (b) Top 25 association results for mean BMI and mean WC based on FBAT p-value; (c) LOD scores of at least 2.0 with accompanying LOD score 1.5 support interval for mean BMI and mean WC
| Trait | SNP | Chromosome | Physical Position (Mb) | GEE p-value | FBAT p-value | Gene |
|---|---|---|---|---|---|---|
| 2a. Top association results for mean BMI and mean WC based on GEE p-value | ||||||
| Mean BMI | rs1106683 | 7 | 130910780 | 1.2*10-07 | 3.2*10-04 | |
| Mean WC | rs4471028 | 8 | 75457530 | 2.0*10-07 | 3.2*10-04 | GDAP1 |
| Mean WC | rs4469448 | 8 | 75457665 | 2.6*10-07 | 0.003 | GDAP1 |
| Mean WC | rs6996971 | 8 | 75455047 | 4.9*10-07 | 0.002 | GDAP1 |
| Mean WC | rs10504576 | 8 | 75429234 | 7.1*10-07 | 0.005 | GDAP1 |
| Mean WC | rs1875517 | 3 | 118790257 | 1.5*10-06 | 0.002 | |
| Mean BMI | rs1106684 | 7 | 130910920 | 1.6*10-06 | 0.002 | |
| Mean BMI | rs1333026 | 13 | 65018785 | 8.1*10-06 | 0.209 | |
| Mean BMI | rs2296465 | 10 | 3299647 | 1.5*10-05 | 0.262 | |
| Mean BMI | rs1374489 | 5 | 19658900 | 1.6*10-05 | 0.348 | CDH18 |
| Mean WC | rs1466113 | 17 | 68676913 | 2.7*10-05 | 0.004 | SSTR2 |
| Mean BMI | rs10486301 | 7 | 18183021 | 2.7*10-05 | 0.016 | |
| Mean BMI | rs2221880 | 5 | 19420500 | 3.0*10-05 | 0.072 | |
| Mean WC | rs1456873 | 4 | 62130929 | 3.1*10-05 | 0.005 | |
| Mean BMI | rs10513097 | 5 | 11406101 | 4.4*10-05 | 0.022 | CTNND2 |
| Mean BMI | rs2361128 | 19 | 62431059 | 4.4*10-05 | 0.004 | ZNF264 |
| Mean BMI | rs2942329 | 5 | 19429660 | 4.5*10-05 | 0.089 | |
| Mean WC | rs4129319 | 4 | 88752564 | 4.7*10-05 | 0.003 | SPARCL1 |
| Mean BMI | rs10509361 | 10 | 77223192 | 5.2*10-05 | 0.044 | C10orf11 |
| Mean BMI | rs2967001 | 5 | 19422000 | 6.0*10-05 | 0.074 | |
| Mean BMI | rs464766 | 3 | 162570294 | 6.1*10-05 | 0.072 | ADMP |
| Mean BMI | rs10487263 | 7 | 123603987 | 7.0*10-05 | 0.036 | |
| Mean BMI | rs4922571 | 11 | 31643025 | 7.0*10-05 | 0.062 | ELP4 |
| Mean BMI | rs7013836 | 8 | 5666540 | 8.2*10-05 | 0.103 | |
| Mean BMI | rs7202384 | 16 | 13658225 | 8.2*10-05 | 0.002 | |
| 2b. Top 25 association results for mean BMI and mean WC based on FBAT p-value | ||||||
| Trait | SNP | Chromosome | Physical Location (Mb) | GEE p-value | FBAT p-value | Gene |
| Mean WC | rs10488165 | 7 | 132594899 | 0.011 | 2.6*10-06 | SEC8L1 |
| Mean WC | rs2206682 | 6 | 56001938 | 0.011 | 4.2*10-06 | COL21A1 |
| Mean WC | rs2223662 | 6 | 56001756 | 0.013 | 5.1*10-06 | COL21A1 |
| Mean WC | rs953536 | 9 | 111569442 | 0.007 | 8.2*10-06 | C9orf84 |
| Mean WC | rs10517461 | 4 | 37789743 | 2.3*10-04 | 2.9*10-05 | TBC1D1 |
| Mean WC | rs7941883 | 11 | 123262095 | 0.084 | 3.0*10-05 | OR8D4|OR4D5|OR6T1 |
| Mean BMI | rs10503776 | 8 | 25765786 | 0.009 | 3.8*10-05 | EBF2 |
| Mean BMI | rs711702 | 3 | 22956280 | 0.143 | 4.0*10-05 | |
| Mean WC | rs4312989 | 6 | 55918441 | 0.075 | 4.2*10-05 | |
| Mean WC | rs10519381 | 5 | 113700141 | 0.01 | 4.4*10-05 | KCNN2 |
| Mean WC | rs10483872 | 14 | 75239061 | 0.018 | 4.5*10-05 | KIAA0998 |
| Mean WC | rs315711 | 9 | 111628006 | 0.008 | 5.4*10-05 | C9orf84 |
| Mean WC | rs4715571 | 6 | 55917006 | 0.03 | 5.9*10-05 | |
| Mean WC | rs667463 | 9 | 111647315 | 0.004 | 7.0*10-05 | C9orf84 |
| Mean BMI | rs7320523 | 13 | 67552774 | 0.193 | 7.4*10-05 | |
| Mean WC | rs3752591 | 22 | 40664016 | 0.001 | 8.5*10-05 | C22orf18 |
| Mean WC | rs1496389 | 5 | 113753570 | 0.018 | 9.8*10-05 | KCNN2 |
| Mean WC | rs1619682 | 7 | 133453958 | 0.14 | 1.0*10-04 | SLC35B4 |
| Mean BMI | rs10492197 | 12 | 66871874 | 0.038 | 1.0*10-04 | IFNG|IL26|IL22 |
| Mean WC | rs10501467 | 11 | 79913437 | 0.037 | 1.1*10-04 | |
| Mean WC | SNP_A-1731932 | 1 | 24035982 | 0.152 | 1.1*10-04 | |
| Mean BMI | rs10512326 | 9 | 103934100 | 0.063 | 1.2*10-04 | SMC2L1 |
| Mean BMI | rs7533902 | 1 | 97791249 | 0.029 | 1.2*10-04 | DPYD |
| Mean BMI | rs2870950 | 12 | 66870973 | 0.034 | 1.2*10-04 | IFNG|IL26|IL22 |
| Mean WC | rs2226351 | 21 | 25259810 | 1.8*10-04 | 1.3*10-04 | |
| 2c. LOD scores of at least 2.0 with accompanying LOD score 1.5 support interval for mean BMI and mean WC | ||||||
| Trait | SNP | Chromosome | Physical Position (bp) | LOD | LOD1.5 Lower Bound (bp) | LOD1.5 Upper Bound (bp) |
| Mean BMI | rs9309153 | 2 | 48856798 | 2.3125 | 44048379 | 64579948 |
| Mean WC | rs1992901 | 2 | 121386899 | 2.2721 | 116579748 | 132195205 |
| Mean BMI | rs10518418 | 1 | 89149134 | 2.0053 | 51727132 | 99668198 |