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. 1968 Apr;52(4):841–867.

Acute effects of 3'-methyl-4-dimethylaminoazobenzene intoxication on rat liver. Structural and functional changes in the endoplasmic reticulum and NADPH-related electron transport.

M Arcasoy, E A Smuckler, E P Benditt
PMCID: PMC2013368  PMID: 4384495

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashworth C. T., Werner D. J., Glass M. D., Arnold N. J. Spectrum of fine structural changes in hepatocellular injury due to thioacetamide. Am J Pathol. 1965 Dec;47(6):917–951. [PMC free article] [PubMed] [Google Scholar]
  2. BRODIE B. B., AXELROD J. The fate of aminopyrine (pyramidon) in man and methods for the estimation of aminopyrine and its metabolites in biological material. J Pharmacol Exp Ther. 1950 Jun;99(2):171–184. [PubMed] [Google Scholar]
  3. CONNEY A. H., SCHNEIDMAN K. ENHANCED ANDROGEN HYDROXYLASE ACTIVITY IN LIVER MICROSOMES OF RATS AND DOGS TREATED WITH PHENYLBUTAZONE. J Pharmacol Exp Ther. 1964 Nov;146:225–235. [PubMed] [Google Scholar]
  4. CONNEY A. H., SCHNEIDMAN K., JACOBSON M., KUNTZMAN R. DRUG-INDUCED CHANGES IN STEROID METABOLISM. Ann N Y Acad Sci. 1965 Mar 12;123:98–109. doi: 10.1111/j.1749-6632.1965.tb12248.x. [DOI] [PubMed] [Google Scholar]
  5. FOUTS J. R., ROGERS L. A. MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYL-CHOLANTHRENE IN RATS. J Pharmacol Exp Ther. 1965 Jan;147:112–119. [PubMed] [Google Scholar]
  6. GILLETTE J. R., BRODIE B. B., LA DU B. N. The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen. J Pharmacol Exp Ther. 1957 Apr;119(4):532–540. [PubMed] [Google Scholar]
  7. HARTMANN H. A. RAT LIVER AFTER N-HYDROXY-2-ACETYLAMINOFLUORENE. ULTRASTRUCTURE. Arch Pathol. 1965 Feb;79:126–134. [PubMed] [Google Scholar]
  8. HUNTER F. E., Jr, GEBICKI J. M., HOFFSTEN P. E., WEINSTEIN J., SCOTT A. Swelling and lysis of rat liver mitochondria induced by ferrous ions. J Biol Chem. 1963 Feb;238:828–835. [PubMed] [Google Scholar]
  9. Jones A. L., Fawcett D. W. Hypertrophy of the agranular endoplasmic reticulum in hamster liver induced by phenobarbital (with a review on the functions of this organelle in liver). J Histochem Cytochem. 1966 Mar;14(3):215–232. doi: 10.1177/14.3.215. [DOI] [PubMed] [Google Scholar]
  10. KLINGENBERG M. Pigments of rat liver microsomes. Arch Biochem Biophys. 1958 Jun;75(2):376–386. doi: 10.1016/0003-9861(58)90436-3. [DOI] [PubMed] [Google Scholar]
  11. Ketterer B., Holt S. J., Ross-Mansell P. The effect of a single intraperitoneal dose of the hepatocarcinogen 4-dimethylaminoazobenzene on the rough-surfaced endoplasmic reticulum of the liver of the rat. Biochem J. 1967 Jun;103(3):692–698. doi: 10.1042/bj1030692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  13. MASON H. S. OXIDASES. Annu Rev Biochem. 1965;34:595–634. doi: 10.1146/annurev.bi.34.070165.003115. [DOI] [PubMed] [Google Scholar]
  14. MUELLER G. C., MILLER J. A. The metabolism of methylated aminoazo dyes. II. Oxidative demethylation by rat liver homogenates. J Biol Chem. 1953 Jun;202(2):579–587. [PubMed] [Google Scholar]
  15. MUKHERJEE T., GUSTAFSSON R. G., AFZELIUS B. A., ARRHENIUS E. EFFECTS OF CARCINOGENIC AMINES ON AMINO ACID INCORPORATION BY LIVER SYSTEMS. II. A MORPHOLOGICAL AND BIOCHEMICAL STUDY ON THE EFFECT OF DIMETHYLNITROSAMINE. Cancer Res. 1963 Jul;23:944–953. [PubMed] [Google Scholar]
  16. Ma M. H., Webber A. J. Fine structure of liver tumors induced in the rat by 3'-methyl-4-dimethylaminoazobenzene. Cancer Res. 1966 May;26(5):935–946. [PubMed] [Google Scholar]
  17. Mason H. S., North J. C., Vanneste M. Microsomal mixed-function oxidations: the metabolism of xenobiotics. Fed Proc. 1965 Sep-Oct;24(5):1172–1180. [PubMed] [Google Scholar]
  18. NASH T. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem J. 1953 Oct;55(3):416–421. doi: 10.1042/bj0550416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Orrenius S., Ericsson J. L., Ernster L. Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study. J Cell Biol. 1965 Jun;25(3):627–639. doi: 10.1083/jcb.25.3.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. PITOT H. C., HEIDELBERGER C. METABOLIC REGULATORY CIRCUITS AND CARCINOGENESIS. Cancer Res. 1963 Nov;23:1694–1700. [PubMed] [Google Scholar]
  21. PORTER K. R., BRUNI C. An electron microscope study of the early effects of 3'-Me-DAB on rat liver cells. Cancer Res. 1959 Nov;19:997–1009. [PubMed] [Google Scholar]
  22. PREHN R. T. A CLONAL SELECTION THEORY OF CHEMICAL CARCINOGENESIS. J Natl Cancer Inst. 1964 Jan;32:1–17. [PubMed] [Google Scholar]
  23. Paul J. S., Reynolds R. C., Montgomery P. O. Inhibition of DNA-dependent RNA polymerase by 4-nitroquinoline-N-oxide in isolated nuclei. Nature. 1967 Aug 12;215(5102):749–750. doi: 10.1038/215749a0. [DOI] [PubMed] [Google Scholar]
  24. REMMER H., MERKER H. J. DRUG-INDUCED CHANGES IN THE LIVER ENDOPLASMIC RETICULUM: ASSOCIATION WITH DRUG-METABOLIZING ENZYMES. Science. 1963 Dec 27;142(3600):1657–1658. doi: 10.1126/science.142.3600.1657. [DOI] [PubMed] [Google Scholar]
  25. REMMER H., MERKER H. J. EFFECT OF DRUGS ON THE FORMATION OF SMOOTH ENDOPLASMIC RETICULUM AND DRUG-METABOLIZING ENZYMES. Ann N Y Acad Sci. 1965 Mar 12;123:79–97. doi: 10.1111/j.1749-6632.1965.tb12247.x. [DOI] [PubMed] [Google Scholar]
  26. RUBIN A., TEPHLY T. R., MANNERING G. J. KINETICS OF DRUG METABOLISM BY HEPATIC MICROSOMES. Biochem Pharmacol. 1964 Jul;13:1007–1016. doi: 10.1016/0006-2952(64)90097-8. [DOI] [PubMed] [Google Scholar]
  27. SOROF S., COHEN P. P. Electrophoretic and ultracentrifugal studies on the soluble proteins of various tumors and of livers from rats fed 4-dimethylaminoazobenzene. Cancer Res. 1951 May;11(5):376–382. [PubMed] [Google Scholar]
  28. SOROF S., COHEN P. P., MILLER E. C., MILLER J. A. Electrophoretic studies on the soluble proteins from livers of rats fed aminoazo dyes. Cancer Res. 1951 May;11(5):383–387. [PubMed] [Google Scholar]
  29. SUGIURA K., KENSLER C. J., CROSSLEY M. L. The carcinogenicity of ethyl derivatives of p-aminoazobenzene. J Natl Cancer Inst. 1955 Apr;15(5 Suppl):1595–1596. [PubMed] [Google Scholar]
  30. Sladek N. E., Mannering G. J. Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats. Biochem Biophys Res Commun. 1966 Sep 8;24(5):668–674. doi: 10.1016/0006-291x(66)90376-7. [DOI] [PubMed] [Google Scholar]
  31. Smuckler E. A., Arrhenius E., Hultin T. Alterations in microsomal electron transport, oxidative N-demethylation and azo-dye cleavage in carbon tetrachloride and dimethylnitrosamine-induced liver injury. Biochem J. 1967 Apr;103(1):55–64. doi: 10.1042/bj1030055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Theron J. J. Acute liver injury in ducklings as a result of aflatoxin poisoning. Lab Invest. 1965 Sep;14(9):1586–1603. [PubMed] [Google Scholar]
  33. Ziegler D. M., Pettit F. H. Microsomal oxidases. I. The isolation and dialkylarylamine oxygenase activity of pork liver microsomes. Biochemistry. 1966 Sep;5(9):2932–2938. doi: 10.1021/bi00873a024. [DOI] [PubMed] [Google Scholar]
  34. Ziegler D. M., Pettit F. H. Microsomal oxidases. I. The isolation and dialkylarylamine oxygenase activity of pork liver microsomes. Biochemistry. 1966 Sep;5(9):2932–2938. doi: 10.1021/bi00873a024. [DOI] [PubMed] [Google Scholar]

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