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Comparison of the Barx2 homeodomain with other homeodomains. The four α helices of the homeodomain are indicated by brackets. Based on crystallographic and NMR studies of homeodomain/DNA interactions (44, 45), black circles indicate residues of the Barx2 homeodomain that are likely to contact bases. Open circles indicate residues that make contacts with the sugar–phosphate backbone of DNA. D, Drosophila; H, human; Hy, hydra; M, mouse; X, Xenopus.
