Table 1.
Inhibition of SIN-1-induced accumulation of PC-OOH
| Conc., μM | Tocopherol | Percentage inhibition†
|
n | |
|---|---|---|---|---|
| Initial rate | Maximum extent | |||
| 5 | α | 34.7 ± 3.3 | 18.8 ± 11.4 | 3 |
| γ | 31.1 ± 17.8 | 33.4 ± 6.9 | 3 | |
| 10 | α | — | — | — |
| γ | 41.2 ± 17.3 | 53.1 ± 12.8 | 3 | |
| 20 | α | 45.2 ± 8.0 | 36.5 ± 6.6 | 4 |
| γ | 64.7 ± 5.0* | 46.6 ± 4.5 | 5 | |
| ‡α and γ | 71.5 ± 2.5** | 51.6 ± 5.8 | 3 | |
†
Calculated from the extent of PC-OOH accumulation measured in the presence and absence of tocopherol (control = 100%). Values are mean ± SEM of n measurements. ∗, Significantly different from the corresponding αT value (P = 0.03). ∗∗, Significantly different from αT (P = 0.02) but not γT.
‡
Total concentration = 40 μM.