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. 2007 Jul 10;36(2):137–151. doi: 10.1007/s12035-007-0036-8

Table 2.

Chemokine receptor expression in astrocytes, microglia, and neurons

Chemokine Receptor Cell type Species Condition RNA Protein References
CCL2 CCR2 astrocyte h Brain, MS, HIV ↑ [96, 97, 173]
Monoculture ↑ ↑ [83, 99, 174–176]
mac Monoculture ↑ [175]
r Brain, EAE, LPS injection ↑ [177, 178]
microglia h Brain, MS, HIV ↑ [96, 173, 179]
Monoculture ↓ + [173, 180]
Glia culture + [99]
r Brain, tumor, LPS injection, NMDA injection ↑ [177, 181, 182]
Monoculture ↑ [88]
m Spinal cord, peripheral nerve injury ↑ [183]
neuron h Brain, HIV + [184]
Monoculture + + [38]
Cell line + + [38]
r Brain and spinal cord + + [161, 177, 185]
Monoculture + + [161, 164]
CXCL10/CCL21 CXCR3 astrocyte h Brain, MS, HIV ↑ [95, 97, 179, 186]
Astrocyte culture ↑ ↑ [84, 98, 175]
Mixed glial culture + [95]
mac Monoculture + [175]
m Monoculture + [84]
microglia h Monoculture + + [7, 84, 98, 114]
Cell line ↑ ↑ [98]
r Cell line ↑/↓ [187]
m Brain, various infectious agents, axotomy ≈/↑ ≈/↑ [125]
Monoculture + ↓ [45, 84]
Cell line ↑/↓ [188]
neuron h Brain, AD + ≈ [95, 179, 189]
Monoculture + + [38]
Cell line + + [38]
mac Brain, HIV + [54]
r Monoculture + [163]
CXCL12 CXCR4 astrocyte h Brain, HIV ↑ [173, 190, 191]
Monoculture ↑ ↑ [85, 90, 98, 99, 175, 192–196]
mac Monoculture ↑ ↑ [85, 175]
r Brain + [197]
Monoculture ↑/↓ ↑/↓ [57, 58, 102, 198]
m Monoculture ↑/↓ ↑/↓ [86, 101, 104, 199, 200]
microglia h Brain and spinal cord, HIV + + [173, 179, 190, 191, 201, 202]
Monoculture + ↓ [98, 99, 191, 202–205]
Cell line ≈ [98]
bab Monoculture ↑ [206]
r Brain + [197]
Monoculture ≈/↑ + [58, 207, 198]
m Cell line + [86]
neuron h Brain, HIV + ≈/↑ [179, 184, 191, 197, 202, 204, 208]
Monoculture + + [38, 85]
Mixed brain culture + + [202]
Cell line + + [38, 191, 209]
mac Brain + [210, 211]
Monoculture + [85]
r Brain + + [57]
Monoculture + + [64, 158]
CX3CL1 CX3CR1 astrocyte h Brain, MS ≈ [113]
Monoculture ↑ + [113, 175]
mac Monoculture ↑ [175]
r Monoculture ≈/↑ ↑ [76, 198, 212]
m Monoculture ↓ ↓ [77, 81, 200]
microglia h Brain, MS ≈ [113]
Brain, HIV ↑ [170]
Monoculture + + [75, 113]
r Brain, ischemia, prion disease, cranial nerve injury, EAE ↑ ↑ [63, 67, 68, 213]
Brain, LPS injection, KA injection ≈ [67]
Spinal cord, peripheral nerve injury ↑ ↑ [171, 172]
Monoculture ↑/↓ ↑ [63, 65, 198, 212, 214]
Cell line ↓ [187]
Brain, LPS injection, KA injection ≈ [67]
m Monoculture ≈ ≈ [77]
neuron h Monoculture + + [75]
Cell line ≈ ↑ [75]
r Brain, LPS injection, KA injection ≈ [67]
Monoculture + + [64, 139]
m Brain, prion disease ↓ [67]
Brain, LPS injection, KA injection ≈ [67]

h human, mac macaque, bab baboon, r rat, m mouse, MS multiple sclerosis, HIV human immunodeficiency virus, EAE experimental autoimmune encephalomyelitis, LPS lipopolysaccharide, NMDAN-methyl-d-aspartatic acid, AD Alzheimer’s disease, KA kainic acid; + present, ≈ present without change in mentioned conditions, ↑ present with increase in mentioned conditions, ↓ present with decrease in mentioned conditions