Table 2.
Summary of the declines in different nAChR subtypes in monkey striatum with nigrostriatal damage
| nAChR subtype | Present on striatal dopamine terminals | Severity of lesion
|
|
|---|---|---|---|
| Moderate | Severe | ||
| α6α4β2β3 | Yes | ↓↓ | ↓↓ |
| α6β2β3 | Yes | - | ↓ |
| α4β2 | Yes | - | ↓ |
| α4β2* | No | - | - |
| α7 | No | - | - |
The α3β2* nAChR subtype is also expressed in monkey striatum and decreased with lesioning. However, the effect of moderate versus severe nigrostriatal damage remains to be determined [87]. The α4β2* receptors may contain either α4β2 or α4α2β2 subunits. Moderate lesion, ≥ 50% decline in the dopamine transporter; severe lesion, ≥ 90% decline in the dopamine transporter; ↓ indicates a decline; - indicates no change.