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. 2006 Feb 27;172(5):747–758. doi: 10.1083/jcb.200511033

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Copyright © 2006, The Rockefeller University Press

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Figure 7. — Keratin 18 and 8 mRNA colocalize in a subpopulation of mRNPs. HeLa cells were trypsinized and replated for 2 h; then they were processed for double FISH to detect keratin 18 and 8 mRNA. (A) For keratin mRNA detection a biotinylated probe specific for keratin 18 mRNA (red) and a digoxigenin-labeled probe specific for keratin 8 mRNA (green) were used. (B) A ventral view of an early spreading HeLa cell hybridized with both K18 (red) and K8 probes (green). Approximately 15% of both types of mRNA signals appeared to colocalize or overlap completely (arrowheads; n = 8 cells; n ≅ 900 mRNPs; P ≅ 0.0004). Bar, 5 μm.