Table I.
EMT markers
Proteins that increase in abundance |
N-cadherin |
Vimentin |
Fibronectin |
Snail1 (Snail) |
Snail2 (Slug) |
Twist |
Goosecoid |
FOXC2 |
Sox10 |
MMP-2 |
MMP-3 |
MMP-9 |
Integrin αvβ6 |
Proteins that decrease in abundance |
E-cadherin |
Desmoplakin |
Cytokeratin |
Occludin |
Proteins whose activity increases |
ILK |
GSK-3β |
Rho |
Proteins that accumulate in the nucleus |
β-catenin |
Smad-2/3 |
NF-κβ |
Snail1 (Snail) |
Snail2 (Slug) |
Twist |
In vitro functional markers |
Increased migration |
Increased invasion |
Increased scattering |
Elongation of cell shape |
Resistance to anoikis |