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. Author manuscript; available in PMC: 2007 Dec 3.
Published in final edited form as: Brain Res. 2006 Mar 9;1091(1):58–74. doi: 10.1016/j.brainres.2006.01.074

Table 2.

Similarities in bone and otoconial development

Bone Otoconia
Early rise in endoplasmic reticulum and mitochondrial Ca2+ Early rise in endoplasmic reticulum and mitochondrial Ca2+
Concentration of Ca2+ in cytoplasmic blebs Concentration of Ca2+ in cytoplasmic blebs
Matrix vesicles provide lipid Globular substance provides lipid
Specific collagen interactions Otolin-1 collagen-like repeats
Glycosaminoglycans in the ECM Glycosaminoglycans in the ECM
Ca2+ actively concentrated in extracellular matrix vesicles Ca2+ actively concentrated in extracellular globular substance
Alkaline phosphatase activity Alkaline phosphatase activity
Carbonic anhydrase activity Carbonic anhydrase activity
Annexins concentrate Ca2+ Otopetrin1 concentrates Ca2+ (?)
PLA binds Ca2+ and lipids Oc90 binds Ca2+ and lipids (?)