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. 1988 Feb;170(2):895–899. doi: 10.1128/jb.170.2.895-899.1988

Opaque-white phenotype transition: a programmed morphological transition in Candida albicans.

E H Rikkerink 1, B B Magee 1, P T Magee 1
PMCID: PMC210739  PMID: 2828333

Abstract

This paper reports that the opaque and white phenotypes of Candida albicans constitute a true high-frequency reversible transition system. The rDNA restriction fragment and orthogonal field alternating gel electrophoresis profiles of opaque and white phenotypes are indistinguishable, and a genetic marker introduced into a white strain is present in all opaque derivatives of this strain. Opaque and white derivatives appear markedly different on a bismuth indicator medium and differ in a number of other respects. We have used bismuth medium to examine the spontaneous and temperature-induced frequencies of transition from opaque to white. The temperature-induced transition from opaque to white does not occur when opaque cells are held in water.

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Selected References

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