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. 2007 Jan 22;204(1):25–31. doi: 10.1084/jem.20061303

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — Defective peripheral lymphocyte compartment in Atg5^−/− chimeras. (A) FACS profiles of donor-derived CD4⁺ and CD8⁺ T cells in the spleens of Atg5^−/− and wild-type chimeric mice 6–10 wk after reconstitution. All cells are pregated on CD45.2⁺ donor-derived cells. (B) The numbers of T cells, B cells, and neutrophils in the spleen of Atg5^−/− and wild-type chimeras. The numbers are derived from multiplying the percentage of CD4⁺ and CD8⁺ T cells, B220⁺, or Gr-1⁺CD11b⁺ CD45.2⁺ cells by the total numbers of splenocytes. p values for comparison between Atg5^−/− and wild-type chimeras are: T cells, P = 0.0267; B cells, P = 0.0001; PMN, P = 0.8785. (C) The numbers of CD4⁺ and CD8⁺ T lymphocytes in the spleen of Atg5^−/− and wild-type chimeras. CD4⁺ T cells, P = 0.0678; CD8⁺ T cells, P = 0.002. (D) The CD4⁺ to CD8⁺ T cell ratio in Atg5^−/− and wild-type chimeras. Shown are data from individual mice. P = 0.0163. All p values are derived from unpaired, two-tailed Student's t test.