TABLE 6.

Flow Cytometric Analysis of Selected T-cell Surface Markers in Peripheral Blood of Patients Receiving Escalating Doses of Anti–CTLA-4 Antibody

	Mean % Change in Positive Cells
	0 to 3 mg/kg	0 to 5 mg/kg	0 to 9 mg/kg

N	18	24	12
CD25⁺ (% CD3⁺CD4⁺)	− 0.5	− 4.7	− 6.8
P	0.8	0.006	0.03
HLA-DR⁺ (% CD3⁺CD4⁺)	+10.1	+10.7	+13.2
P	0.0002	<0.0001	0.0002
HLA-DR⁺ (%CD3⁺CD4⁻)	+11.0	+8.5	+11.5
P	0.01	0.002	0.003
CD69⁺ (% CD3⁺CD4⁺)	− 11.2	− 5.6	− 10.5
P	0.04	0.1	0.1
CD69⁺ (%CD3⁺CD4⁻)	− 12.8	− 11.4	− 18.6
P	0.01	0.004	0.007
CD45RO⁺ (% CD3⁺CD4⁺)	+3.9	+5.7	+9.8
P	0.02	0.0005	0.007
CD45RO⁺ (%CD3⁺CD4⁻)	+6.0	+4.2	+7.0
P	0.03	0.06	0.04

Two-tailed P value using paired t test.