Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1946 Jun 30;84(1):51–59.

FRACTIONATION OF MAMMALIAN LIVER CELLS BY DIFFERENTIAL CENTRIFUGATION

I. PROBLEMS, METHODS, AND PREPARATION OF EXTRACT

Albert Claude 1
PMCID: PMC2135638  PMID: 19871553

Abstract

1. Materials and technical procedures involved in the preparation of liver suspensions have been described and discussed. 2. Liver extracts prepared by the present method appear to contain almost exclusively elements of cytoplasmic origin and can be considered to represent, on a large scale, the cytoplasm of liver cells.

Full Text

The Full Text of this article is available as a PDF (579.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Claude A. FRACTIONATION OF MAMMALIAN LIVER CELLS BY DIFFERENTIAL CENTRIFUGATION : II. EXPERIMENTAL PROCEDURES AND RESULTS. J Exp Med. 1946 Jun 30;84(1):61–89. [PMC free article] [PubMed] [Google Scholar]
  2. Claude A., Potter J. S. ISOLATION OF CHROMATIN THREADS FROM THE RESTING NUCLEUS OF LEUKEMIC CELLS. J Exp Med. 1943 Apr 1;77(4):345–354. doi: 10.1084/jem.77.4.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Claude A. THE CONSTITUTION OF MITOCHONDRIA AND MICROSOMES, AND THE DISTRIBUTION OF NUCLEIC ACID IN THE CYTOPLASM OF A LEUKEMIC CELL. J Exp Med. 1944 Jul 1;80(1):19–29. doi: 10.1084/jem.80.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Claude A. THE CONSTITUTION OF PROTOPLASM. Science. 1943 May 21;97(2525):451–456. doi: 10.1126/science.97.2525.451. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES