Abstract
Evidence has been presented: (1) that macrophages from experimentally produced inflammatory exudates are capable of phagocyting fully encapsulated Type I pneumococci and group A Friedländer's bacilli in the absence of antibody, (2) that the principal mechanisms involved are those of surface phagocytosis, and (3) that the majority of pneumococci ingested by macrophages in antibody-free preparations are ultimately destroyed. The relationship of these phenomena to the mechanism of recovery in pneumococcal and Friedländer's bacillus infections has been briefly discussed.
Full Text
The Full Text of this article is available as a PDF (617.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- LERNER E. M., 2nd, VICTOR J. Effect of filter paper, para-hydroxybenzoic acid, and fixed tissue on phagocytosis. Proc Soc Exp Biol Med. 1952 May;80(1):110–112. doi: 10.3181/00379727-80-19539. [DOI] [PubMed] [Google Scholar]
- Rous P., Jones F. S. THE PROTECTION OF PATHOGENIC MICROORGANISMS BY LIVING TISSUE CELLS. J Exp Med. 1916 May 1;23(5):601–612. doi: 10.1084/jem.23.5.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sale L., Wood W. B. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMONIA DUE TO FRIEDLANDER'S BACILLUS : I. THE PATHOGENESIS OF EXPERIMENTAL FRIEDLANDER'S BACILLUS PNEUMONIA. J Exp Med. 1947 Aug 31;86(3):239–248. doi: 10.1084/jem.86.3.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith M. R., Wood W. B. Relation of Surface Phagocytosis to the Fibrinous Character of Acute Bacterial Exudates. Science. 1949 Aug 19;110(2851):187–188. doi: 10.1126/science.110.2851.187-a. [DOI] [PubMed] [Google Scholar]
- Smith M. R., Wood W. B. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMONIA DUE TO FRIEDLADER'S BACILLUS : III. THE ROLE OF "SURFACE PHAGOCYTOSIS" IN THE DESTRUCTION OF THE MICROORGANISMS IN THE LUNG. J Exp Med. 1947 Aug 31;86(3):257–266. doi: 10.1084/jem.86.3.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILSON A. T. The egestion of phagocytized particles by leukocytes. J Exp Med. 1953 Oct;98(4):305–310. doi: 10.1084/jem.98.4.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WOOD W. B., Jr, SMITH M. R., PERRY W. D., BERRY J. W. Studies on the cellular immunology of acute bacteremia. I. Intravascular leucocytic reaction and surface phagocytosis. J Exp Med. 1951 Dec 1;94(6):521–534. doi: 10.1084/jem.94.6.521. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wood W. B., Irons E. N. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : II. THE EFFECT OF SULFONAMIDE THERAPY UPON THE PULMONARY LESION OF EXPERIMENTAL PNEUMONIA. J Exp Med. 1946 Sep 30;84(4):365–376. doi: 10.1084/jem.84.4.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wood W. B., Smith M. R., Watson B. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : IV. THE MECHANISM OF PHAGOCYTOSIS IN THE ABSENCE OF ANTIBODY. J Exp Med. 1946 Sep 30;84(4):387–402. doi: 10.1084/jem.84.4.387. [DOI] [PMC free article] [PubMed] [Google Scholar]