TABLE 1.
Engineered mutations in ExoN mutant viruses
Virus | Engineered mutationsa | Amino acid substitutionsb |
---|---|---|
rExoN1 | A18426C, U18427A | Asp89Ala |
A18432C, A18433U | Glu91Ala | |
rExoN3 | A18975C, U18976G | Asp272Ala |
C18989G, G18990C | Arg277Ala |
Nucleotide positions refer to the MHV-A59 complete genome sequence (GenBank accession no. AY910861).
Amino acid positions refer to nsp14 sequence (ORF1a/b polyprotein residues 5985 to 6505).