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. 2004 Aug 2;166(3):419–431. doi: 10.1083/jcb.200312074

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Copyright © 2004, The Rockefeller University Press

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Figure 7. — αvβ5-mediated anoikis is independent of FADD. (a and b) Anoikis of αv-transduced H357 cells suspended in presence of caspase inhibitors z-IETD-fmk (caspase 8), z-LEHD-fmk (caspase 9), and z-VAD-fmk (pan caspase). (b) SEM of three experiments. (c) Flow cytometric profiles of αv-expressing H357 cells before and after transduction with eGFP-dNFADD-AU1. GFP fluorescence is shown. (d) SEM of two experiments comparing the percentage of anoikis after 0 or 72 h in suspension. Parental H357 cells were compared with cells transduced with αv (H357αv) alone or in combination with dnFADD. (e) Effect of z-VAD-fmk (CI) and dnFADD on MDCK anoikis was measured by flow cytometry of annexin V–positive cells. Data are from a single representative experiment.