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. 2002 Jun 10;157(6):1071–1082. doi: 10.1083/jcb.200202050

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Copyright © 2002, The Rockefeller University Press

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Figure 8. — A model of double compartmentalization for DOPE diffusion. A DOPE molecule undergoes free diffusion inside a 230-nm compartment for an average of 11 ms, and then hops to an adjacent compartment. It also experiences confinement in the greater 750-nm compartments. The diffusion rate within a 750-nm compartment reflects the rate of hops among 230-nm compartments. The residency time within the 750-nm compartment is 0.33 s on average, which is ∼30 times longer than that for a 230-nm compartment. This residency time was estimated from the macroscopic diffusion rate of Cy3–DOPE.