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. 1999 Jan 18;189(2):441–446. doi: 10.1084/jem.189.2.441

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CD40 activation triggers FasL-dependent hepatocyte and HepG2 apoptosis. (a) Activation of CD40 with mAb induced apoptosis in hepatocytes and HepG2 cells. Treatment of unstimulated cells with NOK-1, a neutralizing Ab to FasL, alone had no effect, whereas NOK-1 inhibited apoptosis induced via CD40 activation. Results shown as percentage of cells positive by ISEL staining. White bars, results for primary hepatocytes; hatched bars, results for HepG2 cells. (b and c) ISEL staining of untreated hepatocytes or cells treated with 1 μg/ml soluble trimeric CD40L, respectively, demonstrating that soluble CD40L also induced hepatocyte apoptosis.

CD40 activation triggers FasL-dependent hepatocyte and HepG2 apoptosis. (a) Activation of CD40 with mAb induced apoptosis in hepatocytes and HepG2 cells. Treatment of unstimulated cells with NOK-1, a neutralizing Ab to FasL, alone had no effect, whereas NOK-1 inhibited apoptosis induced via CD40 activation. Results shown as percentage of cells positive by ISEL staining. White bars, results for primary hepatocytes; hatched bars, results for HepG2 cells. (b and c) ISEL staining of untreated hepatocytes or cells treated with 1 μg/ml soluble trimeric CD40L, respectively, demonstrating that soluble CD40L also induced hepatocyte apoptosis.