Figure 5.
Comparison of decidual morphology in unmanipulated and BM-engrafted RAG-2−/−γc −/− mice at gd 12. A shows a very hypocellular edematous decidua from an unmanipulated RAG-2−/−γc −/− mouse. C is decidua from RAG-2−/−γc −/− mice engrafted with IFN-γ−/− BM. Decidua in these recipients was either necrotic (C) or hypocellular (not shown). B–F show normal decidual morphology in RAG-2−/−γc −/− mice engrafted with B6, SCID, IFN-γRα−/−, or Stat-1−/− BM cells, respectively. Excessive numbers of uNK cells (arrows) were present in the decidua of RAG-2−/−γc −/− recipients of IFN-γRα−/− or Stat-1−/− BM (E and F) compared with control (B). A–F were stained with PAS. Bars, 50 μm.