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. 2001 Oct 1;194(7):915–926. doi: 10.1084/jem.194.7.915

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© 2001 The Rockefeller University Press

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Defective T cell proliferation and IL-2 production upon stimulation with TCR-specific antigen. Purified CD4⁺ T cells from AND TCR transgenic Rac2^−/− or control mice were stimulated with various doses of MCC peptide in the presence of B10BR splenic APCs (A) or I-E^K + CH27 cells (B and C). [³H]Thymidine was pulsed 48 h after stimulation and harvested 12 h later (A and B). To measure IL-2 production, supernatant were harvested 24 h after stimulation and the amount of IL-2 were determined by ELISA (C). Data represent one of four (A) or one of two (B and C) separate experiments.

Defective T cell proliferation and IL-2 production upon stimulation with TCR-specific antigen. Purified CD4⁺ T cells from AND TCR transgenic Rac2^−/− or control mice were stimulated with various doses of MCC peptide in the presence of B10BR splenic APCs (A) or I-E^K + CH27 cells (B and C). [³H]Thymidine was pulsed 48 h after stimulation and harvested 12 h later (A and B). To measure IL-2 production, supernatant were harvested 24 h after stimulation and the amount of IL-2 were determined by ELISA (C). Data represent one of four (A) or one of two (B and C) separate experiments.