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. 1999 May 17;189(10):1631–1638. doi: 10.1084/jem.189.10.1631

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Long-term retention of IEL is not dependent on αEβ7 integrin. Equal numbers of LN cells from OT-I (Ly5.1⁻5.2⁺) and OT-I-αE^−/− (Ly5.1⁺5.2⁺) mice were transferred to normal C57BL/6-Ly5.1⁺5.2⁻ mice. 48 h later, mice were infected with VSV-ova or not (naive). 3 wk later, IELs were isolated and analyzed for expression of CD8, Ly5.1, Ly5.2, and β7 integrin by four-color flow cytometry. Top panel, β7 integrin expression of CD8⁺OT-I-αE^−/− IEL (open histogram) and CD8⁺OT-I-αE^+/+ IEL (filled histogram).