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LACK DNA vaccination provides similar protection as LACK protein plus rIL-12 to BALB/c mice infected with L. major. BALB/c mice (n = 12/group) were initally immunized and boosted 2 wk later with LACK DNA, control DNA (100 μg), or with LACK protein (50 μg) with or without rIL-12 (1 μg). 2 wk after the boost, mice were challenged in the hind footpad with 105 live L. major metacyclic promastigotes. Weekly footpad measurements represent the average foot pad scores ± SEM.
