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. 2005 Jul 4;202(1):47–59. doi: 10.1084/jem.20050538

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Copyright © 2005, The Rockefeller University Press

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Figure 1. — Increased allergen-driven asthmatic inflammation in OVA-challenged Nrf2 ^−/− mice. (A) Total and differential inflammatory cell populations in the BAL fluid of OVA- and saline-challenged Nrf2 ⁺ ^/ ⁺ and Nrf2 ⁻ ^/ ⁻ mice (n = 8). (B) First challenge with OVA. (C) Second challenge with OVA. (D and E) Third challenge with OVA. There was a progressive increase in the total number of inflammatory cells in the BAL fluid of both OVA-challenged Nrf2 ⁺ ^/ ⁺ and Nrf2 ⁻ ^/ ⁻ mice from the first to third challenges. However, the number of inflammatory cells in the BAL fluid of Nrf2^−/ ⁻ OVA mice was significantly higher than in the BAL fluid of Nrf2 ⁺ ^/ ⁺ OVA mice, as well as the respective saline-challenged mice. The number of eosinophils, lymphocytes, neutrophils, and epithelial cells were significantly (*) higher in the BAL fluid of Nrf2 ⁻ ^/ ⁻ OVA mice compared with Nrf2 ⁺ ^/ ⁺ OVA mice. Pretreatment with NAC significantly (*) reduced the inflammatory cells (F), predominantly eosinophils (G), in the BAL fluid of Nrf2 ⁻ ^/ ⁻ OVA mice (n = 6). Data are mean ± SEM. *, P ≤ 0.05.