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. 2005 Jul 4;202(1):47–59. doi: 10.1084/jem.20050538

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Copyright © 2005, The Rockefeller University Press

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Figure 2. — Increased infiltration of inflammatory cells into the lungs of OVA-challenged Nrf2 ^−/− mice. Lung tissues from the saline- and OVA-challenged (third challenge) Nrf2 ⁺ ^/ ⁺ and Nrf2 ⁻ ^/ ⁻ mice (n = 6) were stained with H&E and examined by light microscope (20×). (A) OVA challenge caused a marked infiltration of inflammatory cells into the lungs of Nrf2 ⁻ ^/ ⁻ OVA compared with Nrf2 ⁺ ^/ ⁺ OVA mice. Immunohistochemical staining showed the presence of numerous eosinophils around the blood vessels and airways (B) and in the parenchyma (C) of OVA-challenged (third challenge) Nrf2 ⁻ ^/ ⁻ compared with Nrf2 ⁺ ^/ ⁺ mice. The figure is representative of three experiments (n = 6). AW, airways; BV, blood vessels. H&E staining of the lung sections from the saline-or NAC-treated (7 d before first OVA challenge) Nrf2-deficient mice. The arrows indicate cells staining positively with anti-MBP antibody. (D) Widespread peribronchial and perivascular inflammatory infiltrates were observed in OVA-sensitized mice after antigen provocation (bottom right). Pretreatment of Nrf2-deficient mice with NAC resulted in substantial reduction in the infiltration of inflammatory cells in the peribronchial and perivascular region (bottom left).