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. 2005 Jul 4;202(1):47–59. doi: 10.1084/jem.20050538

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Copyright © 2005, The Rockefeller University Press

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Figure 5. — Nrf2-deficient mice show increased airway responsiveness to acetylcholine challenge. OVA-challenged Nrf2 ⁺ ^/ ⁺ and Nrf2 ⁻ ^/ ⁻ mice (third challenge) were challenged with acetylcholine aerosol by nebulization with an Aeroneb Pro-nebulizer (n = 7). Lung resistance and compliance were measured. The percent increase in elastance (E; panel C) and resistance (R; panel D) to acetylecholine challenge were significantly higher (*, P ≤ 0.05) in the Nrf2 ⁻ ^/ ⁻ OVA mice when compared with Nrf2 ⁺ ^/ ⁺ OVA mice and the respective saline-challenged mice. However, no significant difference in baseline elastance (A) and resistance (B) were observed in both the saline- and OVA-challenged Nrf2 ⁺ ^/ ⁺ and Nrf2 ⁻ ^/ ⁻ mice in the absence of acetylcholine challenge. Data are mean ± SEM.