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. 2002 Aug;120(2):191–201. doi: 10.1085/jgp.20028598

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Copyright © 2002, The Rockefeller University Press

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Figure 4. — Synergistic activation of mCAP1–3 and Sgk1 on ENaC activity. (A) Oocytes were injected with cRNA coding either for α, β, and γFLAG-tagged rENaC subunits (rENaCf) and water (lane 1) or rENaCf together with mCAP1 (lane 2), mCAP2 (lane 3), mCAP3 (lane 4), Sgk1 (lanes 5–8), or both Sgk1 and mCAP1 (lane 6), Sgk1 and mCAP2 (lane 7), and Sgk1 and mCAP3 (lane 8). I_Na was measured in absence (open bar) and after perfusion of trypsin (closed bar) and normalized to I_Na in oocytes injected with rENaC alone. n ≥ 15 measured oocytes per experimental condition taken from Tables I–III. (B) Normalized oocyte cell surface expression of rENaCf in oocytes experiments described in A. Water, lane 1; mCAP1, lane 2; mCAP2, lane 3; mCAP3, lane 4; Sgk1, lane 5; mCAP1 + Sgk1, lane 6; mCAP2 + Sgk1, lane 7; mCAP3 + Sgk1, lane 8. ***, P < 0.001 versus rENaCf + water.