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. 2001 Sep;10(9):1712–1728. doi: 10.1110/ps.12801

Table 2.

Results of a search of the Protein Data Bank for phosphate containing ligands binding to proteins, with known three-dimensional structures, containing one of the pyrophosphate-binding consensus motifs identified in the FAD-family folds of Table 1

Sequence Motif FAD fold PDB Code Protein name Phosphate-containing ligands
GxGxxG(x)17–19E GR 1agr Guanine nucleotide-binding protein guanosine-5′-diphosphate
GR 1vip Phospholipase A2 SO4
GR 1pbo Phospholipase A2 1-o-octyl-2-heptylphosphonyl-sn-glycerole-3-3-phosphoethanolamin
GR 1gia Gi α1 5′-guanosine-diphosphate monothiophosphate
GR 1csn Casein Kinase-1 ATP, SO4
GR 1pgn 6-phosphogluconate dehydrogenase pyrophosphate 2
GR 2cae Catalase S-dioxyneyhionine
RxxxxxGxG PO 1kvr Udp-galactose 4-epimerase uridine-5′-diphosphate, NADH
K(x)7IxxD(x)10D PO 1bfb Basic Fibroblast Growth Factor N,O6-disulfoglucosamine, 1,4-dideoxy-o2-sulfo-glucuronic acid, 1,4-dideoxy-5-dehydro-o2-sulfo-glucuronic acid, SO4
PO 1gts Glutaminyl-tRNA synthetase AMP, ATP
PO 1ad3 Aldehyde dehydrogenase NADH
KxLxxLxxxL PO 1tpu Triosephosphate isomerase Phosphoglycolohydroxamic acid
PO 1cwn Aldehyde reductase NADPH
GxSxxL(x)5G FD 1ajr Aspartate transaminase 2-lysine(3-hydroxy-2-2-methyl-5 phosphonooxymethyl-pyridin-4 ylmethane)