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Neutralization of TM20 envelope clones. The three functional clones were tested for neutralization by MAbs 4E10 and 2F5 and the entry inhibitor T-20 (enfuvirtide) (A) and by polyclonal antibodies from two broadly cross-reactive HIV-1-positive plasma specimens and autologous contemporaneous sera (B). The dotted lines indicate 50% neutralization, with only those values above the line considered positive.
