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Binding to p85 is essential for H1047R-induced cell transformation. (A and B) Cell transformation (focus formation) induced by full-length or p85-binding domain deletion mutants of p110α (δp85BD-p110α). EOT by H1047R is normalized to one. (C) Western blots comparing the p110α expression levels and the phosphorylation levels of AKT and S6K. δp85BD-p110α constructs do not coimmunoprecipitate with endogenous p85α. The assays were carried out as described in Materials and Methods.
