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. 2008 Mar 17;205(3):565–574. doi: 10.1084/jem.20071477

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Copyright © 2008, The Rockefeller University Press

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Figure 3. — AKT* specifically targets a subset of the TGF-β signature. (A) Comparison of the expression values of TGF-β–activated cells transduced with CTRL or AKT* retrovirus (left) compared with a randomized dataset (right). (B) Fold change versus fold change (FcFc) plot comparing the TGF-β–induced signature in AKT*- versus CTRL-transduced cells. Gene expression values for cells activated in the absence of TGF-β and transduced with a CTRL retrovirus were used as the denominator for the Fc. Regions R1 and R3 highlight TGF-β–regulated genes that are refractory to AKT* expression. Regions R2 and R4 highlight TGF-β–regulated genes that are affected by AKT* expression.