Figure 1. .
Pedigrees of the ASD-affected families with de novo variants or unbalanced translocation derivatives. Arrows denote the index subject. In ASD1, the proband has a de novo 277-kb deletion at 22q13.33 and a de novo 1.4-Mb duplication at 20q13.33. In ASD2, the father carries a balanced translocation t(14;22)(q32.33;q13.31); the elder daughter with ASD has inherited the der(22) t(14;22)(q32.33;q13.31), whereas the younger daughter with ADHD inherited the der(14) t(14;22)(q32.33;q13.31). In ASD3, both children have a de novo 4.4-Mb deletion at 22q13.31-33. In ASD4, the proband has a de novo Q321R mutation. The diamond indicates three siblings without ASD who were unavailable for sampling.