Table 3. Correlation of p53, p53R2 expression, and clinical response with histological response to CRT.
Histological response to CRT (n=36)
|
|||||
---|---|---|---|---|---|
Grade 1 | Grade 2 | Grade 3 | Total | P | |
p53 | |||||
(+) | 10 | 2 | 2 | 14 | 0.041 |
(−) | 7 | 9 | 6 | 22 | |
p53R2 | |||||
(+) | 10 | 2 | 0 | 12 | 0.0018 |
(−) | 7 | 9 | 8 | 24 | |
Clinical response | |||||
CR | 0 | 0 | 0 | 0 | 0.0234 |
PR | 10 | 10 | 8 | 28 | |
NC | 7 | 1 | 0 | 8 | |
PD | 0 | 0 | 0 | 0 |
p53(+)/(−)=p53 positive/negative expression; p53R2(+)/(−)=p53R2 positive/negative expression; CR=complete response; PR=partial response; NC=no change; PD=progressive disease.