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. 2001 Aug;85(3):422–427. doi: 10.1054/bjoc.2001.1869

CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation

C Jones 1, A V Nonni 2, L Fulford 3, S Merrett 1, R Chaggar 1, V Eusebi 4, S R Lakhani 1,3
PMCID: PMC2364069  PMID: 11487275

Abstract

2–18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: CGH, myoepithelial, ductal carcinoma, breast, keratin 14, basal cells

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Selected References

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