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. 2008 May 5;181(3):439–446. doi: 10.1083/jcb.200710196

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© 2008 Ma et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Kindlin-2 enhances talin-induced integrin α_IIbβ₃ activation. EGFP-fused β₃ CT binding proteins were transiently transfected into α_IIbβ₃-CHO cells. Their effects on α_IIbβ₃ activation were evaluated by PAC1 binding (A and D) and expression levels were measured by Western blotting with anti-GFP antibody (B and E). Representative FACS histograms of PAC1 binding to talin-H and/or kindin-2 (kind-2) positive cells (C). Error bars (A and D) represent means ± SD (n = 3). *, P < 0.05; **, P < 0.01 (versus vector).