Table 1.
Families with mutations segregated with the tau gene
| Condition, family | No. of affected subjects | No. of autopsied subjects | Affected subjects sampled | Total subjects sampled | Mean onset age ±SD (n) range | Mutation |
|---|---|---|---|---|---|---|
| PPND | 36 | 13 | 17 | 308 | 43.7 ± 5.5 (33) 32–58 | Asn279Lys |
| DDPAC | 13 | 6 | 7 | 33 | 44.8 ± 9.5 (13) 27–56 | Intronic |
| FTD, Montreal | 6 | 1 | 3 | 19 | 57.2 ± 2.1 (5) 55–63 | Pro301Leu |
| FTD, Seattle D | 6 | 2 | 3 | 5 | 49.4 ± 4.8 (5) 42–57 | Pro301Leu |
| FTD, Seattle F | 14 | 1 | 5 | 8 | 61 ± 3.9 (9) 56–67 | Pro301Leu |
| FTD, Oregon EL | 4 | 0 | 2 | 3 | 64.3 ± 7.7 (4) 58–75 | Pro301Leu |