Figure 4. Expression of the E106Q mutant has no effect on CRAC channel currents in cells stably expressing the Orai1 tetramer.
A, inward CRAC channel currents measured at −40 mV in STIM1- stable cells stably expressing the wild-type Orai1 tetramer either alone (black bar) or after transfection with the E106Q mutant Orai1 (red bar). Data are presented as means ± s.e.m.; n = 12 and 7, respectively. B, representative current–voltage relationships for CRAC channel currents measured in STIM1-stable cells stably expressing wild-type Orai1 tetramer either alone (black trace), or after transfection of the E106Q mutant Orai1 (red trace).