Fig 4 Regimens based on diuretics and β blockers versus other active agents for total major cardiovascular events according to age. SBP/DBP difference=overall difference in mean blood pressure during follow-up between group assigned first listed treatment versus group assigned diuretic or β blocker, calculated by weighting difference observed in each contributing trial by number of individuals in trial. Negative blood pressure values indicate lower mean follow-up blood pressure in first listed than in second listed groups