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. 2004 May 18;90(12):2317–2325. doi: 10.1038/sj.bjc.6601879

Table 1. Summary of pharmacokinetic data for abiraterone acetate when given orally in single and multiple dose studies.

Patient Dose (mg m−2) AUC (μM h−1) Cmax (μM) Tmax (h) T1/2α (h) T1/2β (h) Kabs (h)
1 10 ND ND ND ND ND ND
2 10 ND 0.001 2 ND ND ND
3 10 ND 0.018 11 ND ND ND
4 30 ND ND ND ND ND ND
5 30 ND 0.004 4 ND ND ND
6 30 ND 0.006 1 ND ND ND
7 100 0.15 0.012 13 6.5 ND 6.5
8 100 0.09 0.011 0.16 0.97 26.5 0.03
9 100 0.12 0.019 3.7 2.0 28 1.8
10 200 0.39 0.061 2.8 1.59 25.8 3.87
11 500 0.25 0.063 0.8 0.28 29 0.01
12 500 1.68 0.139 3.7 1.83 21 1.8
13 500 0.73 0.06 3.6 1.73 74 1.71
14 500 0.67 0.066 4 1.43 18 1.41
15 500 0.42 0.077 2 0.29 13.4 1.00
16 500 1.38 0.167 2.7 0.05 13.3 1.15
17 200 0.23 0.037 0.69 1.49 28 0.03
18 500 1.23 0.054 1.7 0.19 14.6 0.3
19 500 1.101 0.183 1.51 0.71 14 0.7
20 500 2.08 0.30 1.41 1.59 24 0.12
21 500 3.54 0.62 1.70 1.07 23.2 0.82
22 500 0.34 0.07 2.30 0.79 12.0 0.80
23 500 NE NE NE NE NE NE
24 800 11.66 1.19 3.02 1.32 87 1.34
25 800 2.32 0.43 1.20 0.45 19.9 0.45
26 800 2.84 0.18 3.10 1.73 26.2 1.82

Details of subjects: PT 1–16: single dose study in castrate males; PT 17–20: single dose in noncastrate males; PT 21–26: multidose study in noncastrate males. NE=not evaluated due to problems with the assay; ND=not detectable, plasma concentrations too allow to permit estimation of the pharmacokinetic behaviour of the drug; AUC=area under the concentration time curve; Cmax=maximum concentration, Tmax=time to maximum concentration; T1/2α=initial half-life; T1/2β=terminal half-life; Kabs=absorption rate constant.