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. 2004 Feb 24;90(6):1235–1243. doi: 10.1038/sj.bjc.6601657

Table 1. Candidate VHL-responsive genes in the 786-0.

IMAGE     Fold Reg Fold Reg
ID Abbreviation Gene VHL−/VHL+ H/N
841641 CCND1 Cyclin D1 4.2 4.6
248828 ID3 Inhibitor of DNA binding 3 4 NS
756372 RARRES2 Retinoic acid receptor responder 2 4 NS
345032 RNASE6PL Ribonuclease 6 precursor 3.8 3.3
1407750 IGFBP3 Insulin-like growth factor-binding protein-3 3.6 3.3
47359 EDN1 Endothelin 1 3.4 2
726086 TFPI2 Tissue factor pathway inhibitor 2 3.4 NS
346545 LAMB1 Laminin, beta 1 3.4 NS
110467 CAV2 Caveolin 2 3.3 NS
755506 ANXA4 Annexin A4 3.2 NS
156520 TNFAIP6 Tumour necrosis factor, alpha-induced protein 6=TSG-6 2.9 NS
272942 HP=DKFZp434K121 Hypothetical protein dkfzp434k121 2.9 3.7
40017 HCS Cytochrome c 2.8 NS
163189 CD24 CD24 2.8 NS
272185 RPL27 Ribosomal protein L27 2.8 NS
325822 TGFA Transforming growth factor, alpha 2.6 2.8
298268 BTG1 B-cell translocation gene 1 2.6 NS
279085 MYO9B Myosin-IXB 2.6 NS
324873 ID2 Inhibitor of DNA binding 2 2.5 NS
230218 GCN5L1 General control of amino-acid synthesis (yeast) homolog-like 1 2.5 NS
83231 CYP2B Cytochrome P450, subfamily IIB, polypeptide 6 2.5 NS
855624 ALDH1 Aldehyde dehydrogenase 1 2.5 NS
343990 LOC51226 COPZ2=nonclathrin coat protein zeta-COP 2.4 NS
725454 CKS2 Cyclin -dependent kinase regulatory subunit 2 2.3 NS
139681 NNAT Neuronatin 2.3 NS
287327 IGF1 Insulin-like growth factor 1 2.3 NS
291057 CDKN2C p18-(INK6)=cyclin-dependent kinase 6 inhibitor 2.2 NS
364934 DAPK1 Death-associated protein kinase 1 2 NS
 
142788 SERPINH2 CBP2=collagen binding protein-2=serine protease inhibitor, clade H, 2 0.16 NS
309482 MAPK12 Mitogen activated protein (MAP) kinase 12 0.18 NS
139009 FN1 Fibronectin 0.26 NS
504763 SDC4 Syndecan-4 0.27 0.49
82734 FACL2 Fatty-acid-coenzyme A ligase, long-chain 2 0.30 0.5
491066 ACVR1 Activin A receptor, type 1=serine/threonine protein kinase receptor R1 0.31 NS
266106 YWHAE 14-3-3 epsilon 0.32 NS
325160 NP25 Neuronal protein 25 0.33 NS
785415 LOC51763 SKIP=skeletal muscle and kidney enriched inositol phosphatase 0.34 NS
841059 CAPG Capping protein (actin filament), gelsolin-like 0.36 NS
198904 APMCF1 APMCF1 protein 0.37 NS
489212 PDHA1 Pyruvate dehydrogenase alpha subunit 0.37 NS
825442 PTP4A2 Protein tyrosine phosphatase type IVA member 2 0.38 NS
769959 COL4A2 Collagen, type IV, alpha 2 0.38 NS
549383 PLAB Prostate differentiation factor=MIC-1=macrophage inhibitory cytokine-1 0.38 0.43
384078 ATP6D ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D 0.38 NS
840844 HSPA5 GRP78=78 kDa glucose regulated protein precursor 0.40 NS
489453 SRM300 EST:KIAA0324 0.41 NS
588829 AARS UG5 alanyl-tRNA synthetase 0.41 NS
193913 LYN Tyrosine kinase 0.41 NS
136744 SPOP Speckle-type, poxvirus and zinc-finger domain (POZ) containing, protein 0.42 NS
897177 PGAM1 Phosphoglycerate mutase 1 (brain) 0.42 NS
324437 GRO1 MGSA=melanoma growth stimulatory activity 0.42 NS
868304 ACTA2 Actin, alpha 2 0.43 NS
307553 KRAS2 v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog 0.45 NS
810213 IL1R1 Interleukin-1 receptor, type I 0.46 0.45
742132 ISG15 Interferon-induced 17 kDa protein 0.47 NS
208161 GW128 GW128 protein 0.48 NS
325583 KIAA1538 EST:KIAA1538 0.48 NS

=, nomenclatures represent the same gene; Fold Reg VHL−/VHL+, fold-regulation of each gene by VHL-status as a ratio of expression in 786-0/expression in 786-0/VHL; Fold Reg H/N, fold-regulation of each gene by hypoxia in 786-0/VHL as a ratio of expression in hypoxia/expression in normoxia; NS, not significantly regulated.