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. 2008 Jun 9;205(6):1303–1315. doi: 10.1084/jem.20071393

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© 2008 Ye et al.

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Figure 8. — Reduced organ injury and improved survival in septic EC-rtTA/I-κBαmt mice. (A) EBD leakage index in the lungs, heart, liver, kidney, and intestine of WT and line 2/36 TG mice 24 h after sham or CLP operation. Compared with WT-sham and TG-sham mice, WT-CLP mice showed a marked increase in EBD leakage index in all five organs, which was reversed in TG-CLP mice. The means ± SEM of eight animals are shown. *, P < 0.05 compared with the other three groups. (B) Tissue wet/dry ratio in the lungs, heart, liver, kidney, and intestine of WT and line 2/36 TG mice. Compared with WT-sham and TG-sham mice, WT-CLP mice showed a significantly increased tissue wet/dry ratio, which was reversed in TG-CLP mice. The means ± SEM of eight animals are shown. *, P < 0.05 compared with the other three groups. (C) Survival of WT-CLP and TG-CLP mice. Animals were subjected to CLP and followed for 14 d (no further mortality after 8 d). Compared with WT mice, TG mice showed a significantly improved survival. *, P < 0.0003 compared with WT mice using the log-rank test (21 mice per group).