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. 2008 May 30;9(7):655–661. doi: 10.1038/embor.2008.80

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Copyright © 2008, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.

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The C1 domain of Vav1. (A) Overlap of the C1 domain of Vav1 (orange) with that of the typical C1 domain of PKCδ bound to phorbol-13-acetate (1PTR, blue) and the atypical C1 domain of Raf1 (1FAR, green). The ligand bound to PKCδ is shown in a ball-and-stick representation. (B) Surface representation of the C1 domain of PKCδ with bound phorbol acetate. (C) Surface representation of Vav1 DH–PH–C1 shows a pocket in the C1 domain in the same position in which phorbol acetate is bound to PKCδ (shown for comparison). DH, Dbl homology; PH, pleckstrin homology; PKCδ, protein kinase Cδ.