Table III.
Recognition of gene transfectants by TIL clones MR7, MB4, and M8a
| IFN-γ (pg/ml)
|
|||
|---|---|---|---|
| Expt. 1
|
Expt. 2
|
||
| Transfected Gene | MR7 | MB4 | M8 |
| gp100 | 8 | 94 | 0 |
| MART-1 | 4 | 92 | 0 |
| TYR | 9 | 87 | 0 |
| TRP-1 | 5 | 44 | 0 |
| TRP-2 | >1000 | 114 | 0 |
| MAGE-1 | 5 | 67 | 0 |
| MAGE-3 | 0 | 109 | 0 |
| AIM | 7 | 53 | 0 |
| NY-ESO-1 | 5 | 9 | >1000 |
a
Cytokine release (measured in picograms per milliliter) following coincubation of T cells with 293A2 cells transfected with cDNA encoding known Ags for 24 h was measured using an IFN-γ ELISA (background activity from 293 transfectants has been subtracted).