Table 5.
Model-based population pharmacokinetic parameters of flurbiprofen.
| Parameter | Estimate | 95% Confidence Interval |
|---|---|---|
| CL2C9, uninhibited (L/hr) | ||
| CYP2C9*1/*1 | 1.38 | (1.15, 1.61) |
| CYP2C9*1/*3 | 0.805 | (0.580, 1.03) |
| CYP2C9*3/*3 | 0.384 | (0.215, 0.553) |
| CLnon2C9 (L/hr) | 0.198 | (0.0792, 0.317) |
| V (L) | 8.40 | (7.34, 9.46) |
| Ka (hr−1) | 2.13 | (1.18, 3.08) |
| LAG (hr) | 0.200 | (0.181, 0.219) |
| Variability (CV%) | ||
| CL | 25.6% | (5.9, 35.8%) |
| V | 26.1% | (12.4, 34.6%) |
| Ka | 94.2% | (63.1, 117%) |
| LAG | 14.0% | (1.4, 19.7%) |
| RUV | 47.7% | (43.5, 51.7%) |
V- flurbiprofen volume of distribution, Ka — flurbiprofen first-order absorption rate constant, LAG — flurbiprofen absorption lag time, RUV — residual unexplained variability, CV — coefficient of variation