Table 2.
Human orthologs of Monosiga SH2-containing proteins and their functions
| Ortholog | Function |
|---|---|
| Crk | SH2-SH3 adaptor (RAP/RAC GEFs for adhesion) |
| Grb2 | SH2-SH3 adaptor (SOS, Gab1-MAPK/PI3K) |
| SHP | PTP phosphatase: Src activator, RTK signaling |
| STAT | Transcription factor |
| Cbl | Ubiquitination, receptor trafficking |
| PIK3R (p85) | Phosphoinositide signaling; PI3K regulatory subunit |
| PLCγ | Phospholipase: PI3K/Ca signaling adaptor |
| SHIP2 | Phosphoinositide phosphatase |
| RASA1 | Small GTPase: Ras adaptor |
| Rin | Small GTPase: CDC42 adaptor? |
| Vav | Small GTPase: Rho adaptor |
| Src/Abl/Csk/Tec | Src kinase signaling |
| TNS1 | Cytoskeleton |
| SH2D4 | Unknown |
| Supt6 h | Regulator of chromatin structure. Conserved in yeast, probably non-ptyr-binding |