Table 3.
Relative frequency of HIV-1 replication inhibition by >90% in X4 viruses (n = 12)
| Conc. | AMD3465, % | BMS-C, % | T-1249, % | AMD + BMS-C, % | AMD + T-1249, % | BMS-C + T-1249, % | Triple combination, % |
|---|---|---|---|---|---|---|---|
| Low* | 8 | 33 | 0 | 25 | 33 | 25 | 58 |
| High† | 67 | 58 | 25 | 92 | 100 | 92 | 100 |
| Top‡ | 100 | 58 | 100 | 100 | 100 | 100 | 100 |
*AMD3465, 5 nM; all others, 1 nM, alone and in combinations.
†AMD3465, 50 nM; all others, 10 nM, alone and in combinations.
‡AMD3465, 5 μM; all others, 1 μM, alone and in combinations. At this high concentration of AMD3465, nonspecific effects on some R5 virus infections were also seen.