Figure 4. Relative mRNA expression levels of genes associated with significantly over-represented biological processes.
(A–D) % of relative mRNA expression levels of genes associated with immune responses (A), apoptosis (B), carbohydrate (Impa12, Gyk, Phkb) and lipid metabolism (Crot, Dhrs8, Akr1d1) (C), and energy derivation and biosynthesis (D) in the liver of an independent aging cohort of 130-week old compared to 13-week old wt male mice. For each gene, expression levels in the 130-week old livers are plotted relative to those of 13-week old tissues (red colored dotted line). Error bars indicate S.E.M between replicates (n≥6).